Phytother Res. 2003 May; 17(5): 571-4.

Glycosmis arborea extract as a hepatoprotective agent.

Gomes A, Das M, Sur P, Besra SE, Chakravorty AK, Das B, Ganguly DK, Vedasiromoni JR.

Drug Development Division, Indian Institute of Chemical Biology, Calcutta, India.

Glycosmis arborea is a plant possessing various medicinal properties. The aim of the present study was to investigate the hepatoprotective efficacy of the butanol extract obtained from the aerial parts of the plant. The test sample was prepared by extracting the material through different steps. The extract thus obtained was dissolved in normal saline. Albino rats were prophylactically treated with the extract (i.p.) for 3 weeks. At the end of 3rd week all the groups were injected with hepatotoxic agents. After 48 h of injection, blood was collected and livers were taken out. Different enzymes in the serum were assayed and histopathological study was performed with liver. Glycosmis arborea extract was able to overcome the toxic effects of hepatotoxic agents in terms of lowering the levels of serum GPT, alkaline phosphatase and increased level of SOD in serum. TBARS generation in liver was also altered. Moreover, necrosis of liver produced by carbon tetrachloride was reversed by the extract.Copyright 2003 John Wiley & Sons, Ltd.