Fitoterapia. 2003 Apr; 74(3): 288-90.

Antifungal activity of a thiophene polyine from Leuzea carthamoides.

Chobot V, Buchta V, Jahodárová H, Pour M, Opletal L, Jahodár L, Harant P.

Department of Pharmaceutical Botany and Ecology, Charles University, Faculty of Pharmacy, Heyrovského 1203, Hradec Králové 500 05, Czech Republic.

The thiophene polyine (E)-2-[5-(hept-5-en-1,3-diynyl)-thien-2-yl]-ethan-1,2-diol was isolated from an ethanolic extract of underground parts of Leuzea carthamoides. The thiophene polyine demonstrated significant antifungal activity against all tested species.

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