Fitoterapia. 2003 Apr; 74(3): 231-6.

Analgesic, antipyretic and anti-inflammatory effects of essential oil of Lippia multiflora.

Abena AA, Diatewa M, Gakosso G, Gbeassor M, Hondi-Assah T, Ouamba JM.

Laboratoire de Biochimie et Pharmacologie, FacultÃ© des Sciences de la SantÃ©, UniversitÃ© Marien NGOUABI, Brazzaville, B P 69, Congo. [email protected]

The essential oil of Lippia multiflora Moldenke (Verbenaceae) produced by conventional hydrodistillation was analyzed and studied for its analgesic, antipyretic and anti-inflammatory activities in rats and mice. At the doses used (2, 4 and 8 ml/kg o.s.) the essential oil of L. multiflora showed significant and dose-dependent analgesic effect on acetic acid-induced writhing in mice. Only the dose of 8 ml/kg of essential oil, antagonized hyperexia induced by brewer's yeast. No effect on granuloma formation was observed.