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December 2024

Fitoterapia. 2003 Apr; 74(3): 226-30.

Antimycobacterial flavones from Haplopappus sonorensis.

Murillo JI, Encarnación-Dimayuga R, Malmstrøm J, Christophersen C, Franzblau SG.

Universidad Autónoma de Baja California Sur, Departamento de Agronoma, A P 19-B, La Paz, BCS 23080, Mexico.

Crude extracts of Haplopappus sonorensis (A. Gray) S.F. Blake (Asteraceae), showed activity against Mycobacterium tuberculosis H(37)Rv. By assay-guided fractionation, 5-hydroxy-3,7,4'-trimethoxyflavone (1). 5,7-dihydroxy-3,4'-dimethoxyflavone (2). and 5,4'-dihydroxy-3,7-dimethoxyflavone (3). were identified as the antimycobacterial principles. Compound 2 was the most active compound.


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