Phytomedicine. 2003 Mar; 10(2-3): 185-8.

Evaluation of anti-inflammatory activity of Vernonia cinerea Less. extract in rats.

Mazumder UK, Gupta M, Manikandan L, Bhattacharya S, Haldar PK, Roy S.

Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India. [email protected]

The methanol extract of the whole plant of Vernonia cinerea Less. was evaluated for its anti-inflammatory activity in acute (carrageenin, histamine and serotonin induced rat paw edema) and a chronic model (cotton pouch induced granuloma). The methanol extract (250 and 500 mg/kg(-1) p.o.) exhibited significant activity (p < 0.001) against all phlogistic agents used in a dose dependant manner. In the chronic model (cotton pouch granuloma method) the methanol extract exhibited significant anti-inflammatory activity. All these effects were compared with standard drug phenylbutazone (100 mg/kg(-1) p.o.).