Phytother Res. 2003 Apr; 17(4): 420-1.

Trypsin inhibitory effect of wedelolactone and demethylwedelolactone.

Syed SD, Deepak M, Yogisha S, Chandrashekar AP, Muddarachappa KA, D'Souza P, Agarwal A, Venkataraman BV.

Bioassay Unit, R&D Centre, Natural Remedies Pvt Ltd, 5B, Veerasandra Indl Area, Hosur Road, Bangalore 561 229, India.

Wedelolactone (WL) and demethylwedelolactone (DWL) isolated from Eclipta alba were tested in the trypsin inhibition bioassay (in vitro). Both compounds showed potent activity. IC(50) values of WL and DWL were found to be 2.9 and 3.0 microg/mL respectively.Copyright 2003 John Wiley & Sons, Ltd.