Nat Prod Res. 2003 Apr; 17(2): 91-7.

Antiplatelet and anti-HIV constituents from Euchresta formosana.

Lo WL, Wu CC, Chang FR, Wang WY, Khalil AT, Lee KH, Wu YC.

Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

Phytochemical investigation of the methanol extract of Euchresta formosana resulted in the isolation of thirty-four compounds. Compounds 1, 3-12, 15, 27, 29 and 32-24 were isolated from this species for the first time. These compounds were identified by spectral analyses and tested for antiplatelet aggregation and anti-HIV activities. Among these compounds, tectorigenin (1), 3',4',5-trihydroxyisoflavone (3), and euchretin F (19) were the most effective antiplatelet aggregation compounds; they inhibited both AA- (arachidonic acid) and collagen-induced platelet aggregation. Meanwhile, flemiphyllin (B), quercetin (13), euchretin M (23), and formosanatin C (26) inhibited HIV replication in H9 lymphocyte cells.