Planta Med. 2003 Mar; 69(3): 277-81.

Antibacterial evaluation of cnicin and some natural and semisynthetic analogues.

Bruno M, Rosselli S, Maggio A, Raccuglia RA, Napolitano F, Senatore F.

Some ester derivatives of salonitenolide have been prepared from cnicin, a germacranolide sesquiterpenoid. The compounds were tested for their antibacterial activity. The 8,15-diesters showed a good activity, comparable with that of cnicin. The 15-monoester compounds were not very active showing that esterification at the C-8 position is an important structural feature for antibacterial properties.