Phytother Res. 2003 Mar; 17(3): 279-81.

The protective effect of Allium sativum L. clove aqueous and methanolic extracts against hypoxia-induced lethality in mice.

Hosseinzadeh H, Sadati N.

Pharmaceutical Research Center, Pharmacodynamy and Toxicology Department, School of Pharmacy, Mashhad University of Medical Sciences, PO Box 91775-1365, Mashhad, I.R. Iran. [email protected]

The antihypoxic activity of Allium sativum clove (garlic) aqueous and methanolic extracts was studied in mice.The extracts of garlic showed that the antihypoxic effect was dose-dependent. The minimum effective doses of aqueous and methanolic extracts were 0.2 g/kg and 5.12 g/kg, respectively. Phenytoin, 50 mg/kg, and R-phenylisopropyladenosine (R-PIA), 1.6 mg/kg (R-PIA) as positive controls increased survival time up to 52.5 +/- 2.9 min and 120.5 +/- 6 min, respectively, compared to normal saline (34.73 +/- 0.71 min). The high doses of aqueous (16.9 g/kg) and methanolic (12.8 g/kg) extracts increased survival time up to 73.17 +/- 4.9 and 68.41 +/- 3.7, respectively.These results indicated that the extracts of A. sativum cloves have a protective effect against hypoxia-induced lethality in mice.Copyright 2003 John Wiley & Sons, Ltd.