Maturitas. 2003 Mar; 44 Suppl 1(): S21-9.

Soy isoflavones: hope or hype?

Fitzpatrick LA.

Department of Internal Medicine and Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA.

Approximately 50% of Americans use dietary supplements on a regular basis spending an estimated $20 billion on supplements in the year 2000. Soy contains genistein and daidzein, two phytoestrogens, which work through the estrogen receptor and cause alterations in serum lipids, bone metabolism, and possibly cognition. In this article, we review the issues regarding the interpretation with studies using soy-based isoflavones, discuss their mechanism of action, and review the literature on the effect of these bio-active compounds on lipid metabolism, osteoblasts and osteoclasts, bone markers, bone mineral density, and cognition.