Phytother Res. 2003 Feb; 17(2): 179-82.

A new bioactive steroidal saponin from Sansevieria cylindrica.

Da Silva Antunes A, Da Silva BP, Parente JP, Valente AP.

NÃºcleo de Pesquisas de Produtos Naturiais, LaboratÃ³rio de QuÃmica de Plantas Medicinais, Centro de CiÃªncias da SaÃºde, Universidade Federal do Rio de Janeiro, CEP 21944-970 Rio de Janeiro, RJ, Brasil.

A new steroidal saponin was isolated from the leaves of Sansevieria cylindrica. Its structure was established as (3beta,12beta,15alpha,25S)-26-(beta-D-glucopyranosyloxy)-22-hydroxyfurost-5-en-3-yl 12-O- (6-deoxy-alpha-L-mannopyranosyl)-15-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside. The structural identification was performed using detailed analyses of (1)H and (13)C NMR spectra including 2D NMR spectroscopic techniques (COSY, HETCOR, HMBC and HMQC) and chemical conversions. The steroidal saponin showed no haemolytic effects in the in vitro assays and demonstrated inhibition of the capillary permeability activity.Copyright 2003 John Wiley & Sons, Ltd.