Org Lett. 2003 Feb; 5(4): 535-7.

Asymmetric total synthesis of the proposed structure of the medicinal alkaloid jamtine using the chiral base approach.

Simpkins NS, Gill CD.

School of Chemistry, University of Nottingham, Nottingham, United Kingdom. [email protected]

[reaction: see text] A highly step-economic asymmetric synthesis of the tetracyclic structure assigned to the medicinal alkaloid jamtine has been accomplished using a chiral lithium amide base desymmetrization of a ring-fused imide. The structure synthesized appears to be different from that of the natural product originally reported.