Phytother Res. 2003 Jan; 17(1): 86-8.

Correction of haemorheological disturbances in myocardial infarction by diquertin and ascorbic acid.

Plotnikov MB, Aliev OI, Maslov MJ, Vasiliev AS, Tjukavkina NA.

Laboratory of Blood Circulation Pharmacology, Institution for Pharmacology, Scientific Center of Russian Academy of Medical Sciences, Lenin St. 3, Tomsk 634028, Russia.

In a model of the high blood viscosity syndrome, developed after myocardial infarction in rats, it was observed that a therapy of a combination of diquertin (20 mg/kg) and ascorbic acid (50 mg/kg) for a -period of 6 days, resulted in an improvement of haemorheological indices. The decrease in blood -viscosity was primarily due to an improved deformability of erythrocytes, and to some extent, due to a decrease in the content of plasma fibrinogen and erythrocyte aggregation.Copyright 2003 John Wiley & Sons, Ltd.