J Ethnopharmacol. 2003 Jan; 84(1): 31-5.

Anti-inflammatory, antipyretic and antinociceptive activities of Tabernaemontana pandacaqui Poir.

Taesotikul T, Panthong A, Kanjanapothi D, Verpoorte R, Scheffer JJ.

Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.

Studies on carrageenin-induced rat paw edema, yeast-induced hyperthermia in rat and writhing response induced by acetic acid in mice showed that the alcoholic extract of stems of Tabernaemontana pandacaqui (T. pandacaqui) has significant anti-inflammatory, antipyretic and antinociceptive activities. These activities are due to alkaloidal components since they were also observed when the crude alkaloidal (CA) fraction separated from alcoholic extract was tested in the same models.Copyright 2002 Elsevier Science Ireland Ltd.