Zhongguo Zhong Yao Za Zhi. 2002 Feb; 27(2): 139-43.

[Effects of the zhikuofang on the inflammation and cytostatics of the airway model of bronchiectasis]

Wan YG, Cao SH, Bi JJ, Zhu YH, Zhou Y, Zhou M.

Affiliated Drum Tower Hospital of Medical College of Nanjing University, Jiangsu, Nanjing 210008, China. [email protected]

OBJECTIVE: To explore the effects of Zhikuofang, a TCM prescription, and Ofloxacin on the inflammation and cytostatics of the airway model of bronchiectasis. METHOD: The airway model of bronchiectasis (AMB) was set up and infused with Ps. Aeruginosa. A comparison between the effects of Zhikuofang and Of loxacin on the AMB was made. RESULT: Zhikuofang is better than Ofloxacin in following aspects: lowering the density of inflammation cells in blood, decreasing the volume of tracheal secretion and inhibiting the cytostatics (IL-8 and TNF-alpha) of the trachea tissue, but Ofloxacin is more effective in diminishing the amount of bacteria in trachea flushing liquor. There was no marked difference between them in their histopathy effects on the trachea. CONCLUSION: Zhikuofang probably plays antiphlogistic and bacteriostatic effects by inhibiting the IL-8 and TNF-alpha, resisting secretion, decreasing the inflammation cells and resisting inflammation of trachea.