Zhongguo Zhong Xi Yi Jie He Za Zhi. 2002 Jan; 22(1): 28-9.

[Study on effect of Salvia injection in treating primary nephrotic syndrome and on endothelin and serum interleukin-2 receptor in children]

Bao HY, Yu HL, Wang L.

Affiliated Nanjing Children Hospital of Nanjing Medical University, Nanjing 210008.

OBJECTIVE: To explore the effect and mechanism of Salvia Injection (SI) in treating primary nephrotic syndrome (PNS) in children. METHODS: Forty-four PNS children were randomly divided into conventional steroid treated group (20 cases) and conventional plus SI intervention treated group (24 cases), the levels of serum endothelin (ET), soluable interleukin-2 receptor (sIL-2R) were observed. RESULTS: Before treatment, plasma ET and sIL-2R in PNS children were higher than those in healthy children significantly (P < 0.01). After treatment, the ET and sIL-2R levels were all obviously improved in both treated groups (P < 0.05) and the improvement in the conventional plus SI intervention treated group was more obvious, the difference between the two treated groups after treatment was significant (P < 0.05). CONCLUSION: Conventional treatment supplemented with SI could more effectively improve the levels of plasma ET and SIL-2R in treating PNS children, and hence alleviate the damage of renal tissue.