Zhongguo Zhong Xi Yi Jie He Za Zhi. 2002 May; 22(5): 369-71.

[Study on preventive effect of jiangu granule on osteoporosis in ovariectomized rats]

Lin YP, Ma JH, Feng EY.

Faculty of Orthopedics and Traumatology, Fujian College of TCM, Fuzhou 350003.

OBJECTIVE: To investigate the preventive effect of Jiangu granule (JGG) on experimental primary osteoporosis type I. METHODS: Osteoporosis model was established through ovary resection of female rats. Bone mineral density (BMD) was measured with double energy X-ray absorptiometry. Level of endocrine markers, including osteocalcin (BGP), estradiol (E2) and calcitonin (CT) in serum were examined by RIA. And uterus parameters was calculated also. RESULTS: JGG could significantly increase BMD and uterus index, improve the levels of E2 and CT in serum, at the same time reduce the BGP level. CONCLUSION: JGG can efficiently prevent type I primary osteoporosis or delay its occurrence by enhancing the function of endocrine system, coordinating the action of calcium related hormone, reducing bone turnover rate and increasing BMD.