Zhongguo Zhong Xi Yi Jie He Za Zhi. 2002 May; 22(5): 356-8.

[Effect of si' an capsule combined enalapril on hypertensive trough/peak ratio and circadian rhythm of blood pressure in patients with essential hypertension]

Dong M, Han MX, Liang XL.

Department of Cardiovascular Diseases, First Affiliated Hospital, Anhui College of TCM, Hefei 230031.

OBJECTIVE: To investigate the effect of Si' an Capsule combined Enalapril on hypertensive trough/peak ratio (T/P) and circadian rhythm of blood pressure in patients with essential hypertension (EH). METHODS: Sixty patients with EH of stage II, III were randomly divided into two groups, the 30 patients in the treated group were treated with Si' an capsule combined Enalapril, and the 30 patients in the control group were treated with Enalapril alone. All patients were given 24-hour ambulatory blood pressure monitoring before and after 4 weeks treatment. T/P of systolic and diastolic blood pressure (SBP & DBP) of each group were calculated. Circadian rhythm of blood pressure was observed at the same time. RESULTS: T/P of SBP and DBP in the treated group was 62.4 +/- 7.0% and 66.3 +/- 8.1% respectively, which was obviously higher than that in the control group, 53.3 +/- 6.7% and 60.1 +/- 7.2%, respectively (P < 0.05). The blood pressure circadian rhythm recovering rate in the treated group was 73.3% and in the control group 50%, the difference was insignificant. CONCLUSION: The combination therapy of Si' an capsule and Enalapril could lower the blood pressure smoothly and restore the circadian rhythm of blood pressure in EH patients.