Zhongguo Zhong Xi Yi Jie He Za Zhi. 2002 Aug; 22(8): 597-8.

[Clinical observation on effect of kesuning granule in treating acute onset of chronic bronchitis]

Mao B, Zhang RM, Li TQ.

West China Hospital, Sichuan University, Chengdu 610041.

OBJECTIVE: To prove the effect of Kesuning Granule (KSNG) in treating chronic bronchitis in exacerbation (Phlegm-Heat syndrome) and objectively evaluate its safety. METHODS: The double-blinded, double-dummy and randomized controlled method was adopted to observe 120 patients, who were divided into the treated group (n = 60, treated with KSNG 8 g, three times a day) and the control group (n = 60, treated with Jinbei Tankeqing Granule (JBTKQ) 7 g, three times a day). The therapeutic course for both groups was 6 days. RESULTS: In the treated group, the markedly effective rate was 58.33% and effective rate was 93.33%, while in the control group, they were 51.67% and 91.67% respectively, no significant difference was found between the two groups. For therapeutic effects on TCM syndromes, the markedly effective rate and effective rate in the treated group was 68.33% and 93.33% respectively and in the control group, 66.67% and 90.00% respectively, also showed insignificant difference. The effect initiative time was earlier in the treated group than that in the control group significantly (P < 0.05). No adverse effect was found in the observation. CONCLUSION: KSNG shows a definite clinical effect with no obvious toxic-adverse effects.