Zhonghua Shao Shang Za Zhi. 2002 Feb; 18(1): 32-3.

[An experimental study of the inhibitory effects of Tripterygium extract (LLZ) on hypertrophic scar - derived fibroblasts]

Xie W, Jiang H, Li H.

Department of Burns and Plastic Surgery, General Hospital of Nan Jing Military Region of PLA, Nan Jing, 210002 Jiangsu Province, P.R. China.

OBJECTIVE: To explore the effects of Tripterygium extract (LLZ) on postburn hypertrophic scar - derived fibroblasts, so as to provide us an experimental support for the treatment of postburn hypertrophic scar. METHODS: Hypertrophic scar - derived fibroblasts were harvested and cultured in vitro. A serial concentrations of LLZ (5 x 10(-3), 5 x 10(-4), 5 x 10(-5), 5 x 10(-6) g/L) were added to the culture media. The cellular morphology, proliferating activity and the cytotoxicity of the drug were observed after 24 hours of culture. RESULTS: The fibroblast morphology could be altered by any concentration of LLZ solution. Furthermore, the cell count and the cellular proliferating activity were all decreased obviously by the treatment of LLZ. CONCLUSION: The cell morphology and proliferation activity of postburn scar-derived fibroblasts could all be inhibited by LLZ, and it was the result of its toxic effects.