Vopr Med Khim. 2002 Jul-Aug; 48(4): 368-72.

[Correction of lipid metabolism in rabbits with experimental cholelithiasis]

Bogdarin IuA, Kozlov DV.

Institute of Infant Gastroenterology, Semashko st., 22., Nizhny Novgorod, 603005 Russia.

The effect of 16-20% medicinal preparation "Equalen" on some parameters of lipid metabolism in female rabbits with cholelithiasis induced by 40% clamp of common bile duct was investigated. The total course of Equalen administration for 90-120 days included daily oral administration of Equalen for 7 days followed by 3-4 day interval. The optimal dose was 1.5 ml per day (the effective range of doses varied from 1.2 to 2.0 ml). Such treatment resulted in disappearance of large and medium sized cholesterol formations from gallbladder, normalization of lipid metabolism in organs of hepatoenteric system and lipid composition of bile.