Phytomedicine. 2002 Oct; 9(7): 632-5.

Evaluation of anti-inflammatory activity of Alstonia macrophylla Wall ex A. DC. leaf extract.

Arunachalam G, Chattopadhyay D, Chatterjee S, Mandal AB, Sur TK, Mandal SC.

ICMR Virus Unit Calcutta, I.D. & B.G. Hospital, Beliaghata, Kolkata, India.

Methanolic extract of dried leaves of Alstonia macrophylla Wall ex A. DC. and its fractions were investigated for its anti-inflammatory activity. The extract at a concentration of 200 mg kg(-1) and 400 mg kg(-1), p.o. and its fractions at 25 mg kg(-1) and 50 mg kg(-1), p.o. showed the significant dose dependent antiinflammatory activity in carrageenan and dextran-induced rats hind paw edema (acute models) as well as in cotton pellet-induced granuloma (chronic model) in rats. Anti-inflammatory activity of the tested extract and its fractions was comparable with that of the standard drug Indomethacin (10 mg kg(-1)).