Phytother Res. 2002 Dec; 16(8): 737-9.

Investigation on the wound healing activity of oleo-resin from Copaifera langsdorffi in rats.

Paiva LA, de Alencar Cunha KM, Santos FA, Gramosa NV, Silveira ER, Rao VS.

Departamento de Fisiologia e Farmacologia, Universidade Federal do CearÃ¡, C.P. 3157, 60430-270, Fortaleza. CE, Brasil.

The wound healing activity of oleo-resin from Copaifera langsdorffii Desf. (Leguminaceae) bark was evaluated in rats on experimental wounds. The oleo-resin was tested by monitoring wound contraction in excised wounds and by measuring tensile strength in healing incision wounds. The topical application of oleo-resin at a concentration of 4% accelerated wound contraction in open wounds. The mean values of wound contraction in oleo-resin treated rats on day 9 was 84.05% +/- 2.37% as against 51.29% +/- 9.54% seen in controls and the difference was statistically significant (p < 0.05). No significant differences in the rates of wound contraction were observed on days 12, 15, 18 and 21. Also, the tensile strength in healing incised wounds was found to be significantly higher in the group of animals treated with 4% oleo-resin on day 5 but not on days 7 and 12 (controls: 35.95 +/- 7.44 g/cm; oleo-resin: 71.48 +/- 5.77 g/cm; p < 0.05). These results indicate the beneficial effect of C. langsdorffii oleo-resin on wound healing and justify its traditional use for the treatment of wounds.Copyright 2002 John Wiley & Sons, Ltd.