Planta Med. 2002 Nov; 68(11): 995-8.

Polyphenols from the heartwood of Cercidiphyllum japonicum and their effects on proliferation of mouse hair epithelial cells.

Towatari K, Yoshida K, Mori N, Shimizu K, Kondo R, Sakai K.

Department of Forest and Forest Products Sciences, Faculty of Agriculture, Kyushu University, Fukuoka, Japan.

The methanol extract of heartwood of Cercidiphyllum japonicum (Cercidiphyllaceae) stimulated proliferation of mouse hair epithelial cells, similar to minoxidil and procyanidin B-2. (+)-Taxifolin ( 2), quercetin ( 3), myricetin ( 4), (+)-dihydromyricetin ( 5) and gallic acid ( 6) were isolated from C. japonicum and showed significant proliferative activities on the hair epithelial cells.