Planta Med. 2002 Nov; 68(11): 980-5.

Cytotoxic amides from Piper sintenense.

Chen JJ, Huang YC, Chen YC, Huang YT, Wang SW, Peng CY, Teng CM, Chen IS.

Department of Pharmacy, Tajen Institute of Technology, Pingtung, Taiwan, Republic of China. [email protected]

A new alkaloid, pipersintenamide ( 1), together with fourteen known compounds, have been isolated from the whole plant of Piper sintenense. The structures of these compounds were elucidated by spectroscopic analysis. Pipersintenamide, sintenpyridone, sarmentine, and 1-(3,4-methylenedioxyphenyl)-1 E-dodecene at 20 microg/ml exhibited effective cytotoxicities (cell survival < 15 %) against CCRF-CEM, HL-60, PC-3, and HA22T cell lines.