Eksp Klin Farmakol. 2002 Jul-Aug; 65(4): 19-22.

[Rhodiola rosea extract for prophylaxis of ischemic cerebral circulation disorder]

PogorelyÄ VE, Makarova LM.

Pharmacology Department, State Pharmaceutical Academy, Pyatigorsk, pr. Kalinina 11, 357532 Russia.

It was experimentally established that prophylactic introduction of a Rhodiola Rosea extract prevents the ischemic brain damage development. A course administration of the drug in a dose of 700 mg/kg arrests the development of hyper- and hypoperfusion in cerebral circulation, weakens the postischemic hyperglycemic reaction, lowers oxygen extraction by cerebral tissues, suppresses lactate acidosis, promotes pyruvate participation in metabolic processes inhibits edema swelling, prevents the "calcium paradox" development, and decreases manifestations of the lipid peroxidation processes.