J Nat Prod. 2002 Nov; 65(11): 1707-8.

Cytotoxic diarylheptanoids from the roots of Juglans mandshurica.

Lee KS, Li G, Kim SH, Lee CS, Woo MH, Lee SH, Jhang YD, Son JK.

College of Pharmacy, Yeungnam University, Gyongsan, 712-749, Korea.

A new (2) and three known diarylheptanoids (1, 3, and 4), along with one known sesquiterpenoid (5), were isolated from the roots of Juglans mandshurica, and their structures were elucidated on the basis of spectroscopic studies. Four of these compounds (2-5) exhibited moderate cytotoxicities against human colon carcinoma and human lung carcinoma cell lines with IC(50)'s ranging from 2 to 25 microg/mL.