Carcinogenesis. 2002 Nov; 23(11): 1961; author reply 1963.

Redox-regulated mechanism may account for zerumbone's ability to suppress cancer-cell proliferation.

Hoffman A, Spetner LM, Burke M.

A recent report shows that zerumbone (ZER) inhibits the proliferation of, and induces apoptosis in, colon cancer cells. We suggest a mechanism for these phenomena, based on our recently proposed redox model of cell proliferation which stresses the importance of intracellular redox potential E in the control of proliferation of normal and cancer cells.