Pharmacol Res. 2002 Nov; 46(5): 453-8.

Effect of Sinpo-Tang on the mast cell-mediated anaphylactic reactions.

Jeong HJ, Yi JM, Hong SH, Kong JY, Kim KS, Won JH, Cho KH, Shin TY, Kim HS, Kim HM.

College of Pharmacy, Wonkwang University, KI Co. Ltd., Iksan, Jeonbuk 570-749, South Korea.

The herbal formulation Sinpo-Tang (SPT) has long been used for various allergic diseases. We investigated the effect of SPT on the mast cell-mediated anaphylactic reactions in vivo and in vitro murine models. SPT dose dependently inhibited compound 48/80-induced ear swelling response and histamine release. SPT (0.001-0.1g/kg) significantly inhibited passive cutaneous anaphylaxis (PCA). The mast cell number was markedly decreased at the SPT-treated PCA site. In addition, SPT decreased intracellular calcium levels of activated mast cells. These results suggest that SPT inhibit the anaphylactic degranulation of mast cells through decrease of the intracellular calcium level.