Zhonghua Liu Xing Bing Xue Za Zhi. 2002 Jun; 23(3): 213-7.

Retrospective study of adverse events in patients with rheumatoid arthritis treated with second-line drugs.

Jiang L, Zhao N, Ni L.

Zhongshan Hospital, Fudan University, Shanghai 200032, China.

OBJECTIVE: To evaluate rates on the adverse side effect and discontinuation of second-line drugs frequently used in the treatment of rheumatoid arthritis (RA). METHOD: Eight hundred and sixty-four RA patients were studied in a retrospective program. RESULTS: Upper abdominal discomfort was most commonly seen when using second-line drugs. Rash was often associated with D-penicillamine (20.6%) and Sinomenium therapy (13.7%). Methotrexate (MTX) was uniquely characterized by substantial upper GI toxicity (32.2%) and Tripterygium wilfordii Hook. f. (TWH) (14.4%) by menstrual abnormality. Sulfasalazine users reported adverse events including upper abdominal trouble (39.0%), nausea (7.3%) and anorexia (7.3%) while the risk of GI malaise was greater. Patients taking hydroxychloroquine complained of blurred vision (19.6%) but no one went blind. Toxic side effects seemed to be the most common reasons for stoppages, and the patients taking MTX had the lowest discontinuation rate. Combination of D-penicillamine and Methotrexate did not increase the incidence of adverse events. CONCLUSIONS: Knowledge on these different patterns of toxicity provided choices in the selection of second line agents for particular RA patients. However, long-term monitor are required when drugs are being used.