Phytother Res. 2002 Nov; 16(7): 686-8.

Evaluation of antipyretic potential of Leucas lavandulaefolia (Labiatae) aerial part extract.

Mukherjee K, Saha BP, Mukherjee PK.

Department of Pharmaceutical Technology, Faculty of Engineering and Technology, Jadavpur University, Calcutta - 700032, India.

Methanol extract of Leucas lavandulaefolia (LLFE) was subjected to antipyretic evaluation with yeast-induced pyrexia in rats. A yeast suspension (10 mL/kg, s.c.) increased the rectal temperature 19 h after administration. The extract at doses of 100, 200, 400 mg/kg (i.p.) produced significant dose dependent lowering of body temperature in yeast-provoked elevation of body temperature in rats. The antipyretic effect produced was comparable to that of a standard antipyretic drug, paracetamol.Copyright 2002 John Wiley & Sons, Ltd.