Fitoterapia. 2002 Oct; 73(6): 520-2.

Molluscicidal and radical scavenging activity of quinones from the root bark of Caryopteris x clandonensis.

Hannedouche S, Souchard JP, Jacquemond-Collet I, Moulis C.

Laboratoire Pharmacophores Redox, Phytochimie et Radiobiologie, FacultÃ© des Sciences Pharmaceutiques, 35 Chemin des MaraÃ®chers, F-31062 Toulouse Cedex 04, France. [email protected]

In the search for new molluscicidal natural products, the activity of the chloroform extract of the root barks of Caryopteris x clandonensis was tested. The LC(100) was <5 ppm. The fractionation and purification of the extract afforded 15-deoxyfuerstione, fuerstione and alpha-caryopterone as the main compounds. These compounds were tested against the snail Bulinus truncatus, an intermediate host snail of a schistosomiasis parasite and showed strong molluscicidal activity with LC(100)<4 ppm. In addition, they were found to have potent radical scavenging properties on superoxide radical.Copyright 2002 Elsevier Science B.V.