Fitoterapia. 2002 Oct; 73(6): 508-10.

Brine shrimp lethality bioassay of selected Indian medicinal plants.

Padmaja R, Arun PC, Prashanth D, Deepak M, Amit A, Anjana M.

Bioassay Unit, Research & Development Centre, Natural Remedies Pvt Ltd, Plot No 5B, Veerasandra Indl Area, Hosur Road, Bangalore 561 229, India.

Ethanolic extracts of six Indian medicinal plants, piperine, guggulsterone E and guggulsterone Z were tested for cytotoxicity using brine shrimp lethality test. Piper longum showed most potent cytotoxic activity. Piperine, guggulsterone E and guggulsterone Z showed potent activity with LC(50) 2.4, 8.9 and 4.9, respectively.Copyright 2002 Elsevier Science B.V.