Fitoterapia. 2002 Oct; 73(6): 484-9.

Pimarane diterpene from Viguiera arenaria (Asteraceae) inhibit rat carotid contraction.

Ambrosio SR, Tirapelli CR, Bonaventura D, De Oliveira AM, Da Costa FB.

Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, USP, Ribeirão Preto, Brazil.

ent-Pimara-8(14),15-dien-19-oic acid (PA) isolated from Viguiera arenaria (Asteraceae; Heliantheae) inhibited rat carotid rings contraction induced by phenylephrine (10(-8) mol/l) or potassium chloride (45 mmol/l) at concentration ranging from 5 to 20 microg/ml. This inhibitory effect was not reversible after the removal of this compound from the medium bath.Copyright 2002 Elsevier Science B.V.

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