Planta Med. 2002 Sep; 68(9): 843-5.

Anti-inflammatory sesquiterpene lactones from Lourteigia ballotaefolia.

Rosas-Romero A, Manchado CM, Crescente O, Acosta M, Curini M, Epifano F, Marcotullio MC, Rosati O, Tubaro A, Sosa S.

Departamento de QuÃmica, Universidad SimÃ³n BolÃvar, Caracas, Venezuela.

Three sesquiterpene lactones were isolated from Lourteigia ballotaefolia (H. B. K.). 9beta-hydroxy-atripliciolide-8- O-tiglate ( 1) was isolated for the first time from this plant and was previously reported in Conocliniopsis prasiifolia (DC) K. et R., 9beta-hydroxy-atripliciolide-8- O-(5'-acetoxytiglate) ( 2) had been already reported in this species. The minor component, 9beta-(tigloyloxy)-atripliciolide, is a new compound. The anti-inflammatory activity of compounds 1 and 2 was evaluated using the croton oil ear test in mice.