Am J Chin Med. 2002 ; 30(2-3): 235-43.

Ameliorative effect of Silene aprica on liver injuries induced by carbon tetrachloride and acetaminophen.

Ko YJ, Hsieh WT, Wu YW, Lin WC.

Graduate Institute of Chinese Pharmaceutical Sciences, China Medical College, Taichung, Taiwan, ROC.

The effect of oral administration of a 50% ethanol extract of Silene aprica (SA) on acute liver injury was examined in rats intoxicated with carbon tetrachloride (CCl4) and acetaminophen. The results indicated that SA protected the liver from CCl4- and acetaminophen-induced injury as judged by morphological and biochemical observations. An increase in both lipid peroxidation (LPO) and triglyceride concentrations occurred in the liver with CCl4 injection, SA administration significantly reduced these changes.