Eksp Klin Farmakol. 2002 May-Jun; 65(3): 66-70.

[Pharmacological properties od steroid glycosides from Ruscus ponticus]

Abuladze GV, Mulkidzhanian KG, Novikova ZhN.

Department of Pharmacology, Kuteladze Institute of Pharmaceutical Chemistry, ul. P. Saradzhishvili 36, Tbilisi, 380059 Republic of Georgia.

Some pharmacological properties of the sum of steroidal glycosides (ruscoponin preparation) extracted from underground parts of Ruscus ponticus were studied. The drug exhibits a pronounced antiexudative effect (related to the alpha 1-adrenergic activity) on the models of formalin edema and pouch granuloma in rats and a thermal rectum inflammation in mice. The drug exhibited no hepato-, nephro-, and gastrotoxicity.