J Tradit Chin Med. 2002 Jun; 22(2): 87-92.

A clinical and experimental study on the protective effects of jiangzhi tongmai fang on endothelial injury.

Wang Y, Niu F, Zhao M, Zhong B, Hao J, Yan W, Lu X, Wang W, Li Q, Lin Q, Dai Y, Zhao Y, Xiao M, Tang L, He L, Jiang X, Guo W, Wang S, Lu W.

Dongzhimen Hospital, Beijing TCM University, Beijing 100700.

31 cases of atherosclerosis (AS) were treated with Jiang Zhi Tong Mai Fang ([symbol: see text], formula of JZTMF), and its effect was compared with 30 cases treated with lovastatin in the control group. Clinically, the JZTMF formula showed an effect of regulating blood lipids, and therefore it was antiatherosclerotic. The mechanism is, probably, restoration of the function of endothelial cells (EC) by increasing the synthesis of 6-keto-PGF1 alpha and decreasing the release of endothelin (ET) as evidenced in the experimental study.