J Asian Nat Prod Res. 2002 Sep; 4(3): 179-83.

Cytotoxic macrocyclic trichothecenes from the mycelia of Calcarisporium arbuscula Preuss.

Yu NJ, Guo SX, Lu HY.

Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing.

A new cytotoxic macrocyclic trichothecene calcarisporin B1 (1), and two known compounds roridin H (2) and roridin J (3) were isolated from the cultured mycelia of Calcarisporium arbuscula Preuss. The structure of 1 was determined to be 8alpha-acetoxy roridin H on the basis of spectral data. The cytotoxic activities of 1-3 were evaluated in vitro.