Phytother Res. 2002 Jun; 16(4): 395-7.

Anticonvulsant and sedative effects of Salvadora persica L. stem extracts.

Monforte MT, Trovato A, Rossitto A, Forestieri AM, D'Aquino A, Miceli N, Galati EM.

Pharmaco-Biological Department, School of Pharmacy, University of Messina, Vill. SS. Annunziata, 98168 Messina, Italy.

The effect of Salvadora persica L. stem extracts on the potentiation of sodium pentobarbital activity and on generalized tonic-clonic seizure produced by pentylenetetrazol (PTZ) on the rat is reported. The extracts of Salvadora persica L. extended sleeping-time and decreased induction-time induced by sodium pentobarbital; in addition it showed protection against pentylenetetrazol-induced convulsion by increasing the latency period and diminishing the death rate.Copyright 2002 John Wiley & Sons, Ltd.