Neoplasma. 2002 ; 49(2): 114-6.

Possible genotoxic activity of extracts of Bryonia alba roots on human lymphocytes and transformed cells.

Nersesyan AK, Collins AR.

Laboratory of Carcinogenesis, Cancer Research Center, Yerevan, Armenia. [email protected]

Bryonia alba roots (BAR) are widely used as an adaptogenic and restorative drug with immunomodulatory and stress-protective properties that increase the non-specific resistance of an organism toward harmful stimuli. Potential genotoxic activity of aqueous and methanol extracts of BAR was studied on human normal (lymphocytes) and transformed (HeLa and Caco-2) cells using single cell gel electrophoresis (the comet assay). The results obtained did not show any evidence of genotoxic effects of BAR.