Methods Find Exp Clin Pharmacol. 2002 Mar; 24(2): 77-9.

Modulatory effect of Cyclea peltata Lam. on stone formation induced by ethylene glycol treatment in rats.

Christina AJ, Packia Lakshmi M, Nagarajan M, Kurian S.

Department of Pharmacology, K.M. College of Pharmacy, Tamil Nadu, India. [email protected]

The inhibitory effect of the root of Cyclea peltata Lam. on nephrolithiasis induced in rats by feeding with ethylene glycolated water (1%) for 35 days was summarized. Ethylene glycol administration led to oxalate stone formation, as indicated by its high level in urine. Complementary to this anion, the cation calcium level in urine was elevated. These two ions may have contributed to the formation of calcium oxalate stones. In addition to high serum potassium, a low serum magnesium level contributed to stone formation. Simultaneous administration of the powdered root of Cyclea peltata resulted in decreased urinary oxalate and calcium. Likewise, serum potassium was lowered and magnesium was elevated. These observations provided the basis for the conclusion that this plant inhibits the stone formation induced by ethylene glycol treatment.