Eksp Klin Farmakol. 2002 Jan-Feb; 65(1): 41-3.

[Hepatoprotective effect of plant preparations]

Katikova OIu, Kostin IaV, Tishkin VS.

Department of Experimental and Clinical Pharmacology, Biochemistry, and General Chemistry, Ul'yanovsk State University, ul. K. Libknekhta 1, Ul'yanovsk, 432063 Russia.

The hepatoprotector activity of original compositions of plant origin, containing beet and carrot juices, decoction of dog rose fruits, and extracts of corn silk, peppermint leaves, and common horsetail herbs was studied on an acute hepatitis model induced by tetrachloromethane. An analysis of the data on the hepatocyte cytolysis, cholestasis, lipid peroxidation, and antioxidant system of blood serum showed that the preparations possess membranoprotector and antioxidant properties. This was manifested by a decrease in the activity of alanine aminotransferase and in the levels of total bilirubin and the final (malonaldehyde) and intermediate (diene conjugates) lipid peroxidation products, and by the absence of decline in the level of endogenous alpha-tocopherol and in the activity of glutathione-dependent enzymes.