Phytomedicine. 2002 Mar; 9(2): 146-52.

Structure-antiemetic-activity of some diarylheptanoids and their analogues.

Yang Y, Kinoshita K, Koyama K, Takahashi K, Kondo S, Watanabe K.

Department of Pharmacognosy and Phytochemistry, Meiji Pharmaceutical University, Tokyo, Japan.

The structure-activity relationship of diarylheptanoids and their analogues inhibitory of emesis induced by copper sulfate in young chicks was investigated by testing 19 compounds. The compounds are 5 diarylheptanoids isolated from Alpinia katsumadai (Zingiberacea), 5 chemical derivatives of them, 6 analogues isolated from Zingiber officinale rhizome (Zingiberaceae), and 3 analogues available on the market. Among them, two types of essential functional structure of diarylheptanoids and their analogues showed the inhibitory effects against emesis.