Fitoterapia. 2002 Apr; 73(2): 116-20.

Investigations on the antinociceptive activity of crude extracts from Croton cajucara leaves in mice.

Campos AR, Albuquerque FA, Rao VS, Maciel MA, Pinto AC.

Departamento de Fisiologia e Farmacologia, Universidade Federal do CearÃ¡, Caixa Postal-3157, 60430-270, Fortaleza, CE, Brazil.

The crude leaf extracts of Croton cajucara Benth. were studied for their antinociceptive property in chemical and thermal models of nociception in mice. All the tested extracts (hexanic, chloroformic and methanolic), at oral doses of 100 and 200 mg/kg demonstrated significant inhibition of acetic acid-induced writhing and the second phase response of formalin, but did not manifest a significant effect in hot-plate test.