Phytomedicine. 2002 Jan; 9(1): 3-8.

Recent findings of green tea extract AR25 (Exolise) and its activity for the treatment of obesity.

Chantre P, Lairon D.

Laboratoires Arkopharma, Carros, France. [email protected]

The green tea extract AR25 is an 80% ethanolic dry extract standardized at 25% catechins expressed as epigallocatechin gallate (EGCG). In vitro, green tea extract AR25 exerts a direct inhibition of gastric and pancreatic lipases and a stimulation of thermogenesis. In an open study, the effects of extract AR25 were evaluated in moderately obese patients. After 3 months, body weight was decreased by 4.6% and waist circumference by 4.48%. These results suggest the green tea extract AR25 to be a natural product for the treatment of obesity, which exerts its activity by several ways: inhibition of lipases and stimulation of thermogenesis.