Biol Pharm Bull. 2002 Feb; 25(2): 260-3.

Antipruritic effect of Cnidii Monnieri Fructus (fruits of Cnidium monnieri CUSSON).

Matsuda H, Ido Y, Hirata A, Ino Y, Naruto S, Amamiya T, Kubo M.

Faculty of Pharmaceutical Sciences, Kinki University, Higashiosaka, Osaka, Japan. [email protected]

Antipruritic effects of 70% ethanol extract (CM-ext) of Cnidii Monnieri Fructus (dried fruits of Cnidium monnieri CUSSON, Umberifferae) were investigated. In mice, an oral administration of CM-ext (200 and 500 mg/kg) inhibited compound 48/80-induced scratching behavior without influence on spontaneous locomotion. Isopimpinellin (3) and osthol (1), coumarin derivatives isolated from CM-ext, showed an inhibitory effect on compound 48/80-induced scratching behavior.