Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001 May; 21(5): 346-8.

[Treatment of lumbar intervertebral disk prolapse by estradural injection of mailuoning and its influence on dynorphin A in cerebrospinal fluid]

Cheng W, Dong FH.

Xiyuan Hospital, China Academy of TCM, Beijing 100091.

OBJECTIVE: To explore the modulating effects of extradural injection of Mailuoning on analgesic function. METHODS: Twenty patients of lumbar intervertebral disk prolapse were treated by extradural injection of Mailuoning, the spontaneous release of dynorphin A (Dyn-A) in cerebrospinal fluid (CSF) before and after treatment were measured and compared with that of the 20 cases in the control group to determine the therapeutic effect of Mailuoning. RESULTS: After treatment, the concentration of Dyn-A in CSF in the treated group increased remarkably, but displayed no significant difference to normal healthy group (P > 0.05), while that in the control group there was significant difference between them (P < 0.01). CONCLUSION: Mailuoning has the modulatory effect on analgesia function and lumbar intervertral disk prolapse was treated by means of its Dyn-A elevating action.