Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001 May; 21(5): 328-31.

[Clinical and experimental study on effect of shuanghuang shengbai granule on myelosuppression induced by chemotherapy and ultrastructure observation of bone marrow in mice]

Xu ZY, Zhu YW, Zhou WD.

Department of Oncology, Longhua Hospital, Shanghai University of TCM, Shanghai 200032.

OBJECTIVE: To observe the leukocyte increasing effects of Shaunghuang Shengbai Granule (SHSBG) in tumor patients treated by chemotherapy (CT) and its function on bone marrow hematopoietic microenvironment in mice. METHODS: Patients of non-small-cell lung cancer and breast, gastric or intestinal cancer, who were retreated with CT, were enrolled and divided into 4 groups randomly. The 28 cases in the treated group 1 received SHSBG and CT simultaneously. The 27 cases in the treated group 2 also received firstly CT, and SHSBG started when WBC count lowered to less than 4 x 10(9)/L after CT. The control group 1 and 2 (n = 33 and n = 24) was treated by the method similar to that applied to the treated group 1 and 2 respectively but with Rubidate instead of SHSBG. Experimental study of observing bone marrow ultrastructure in mice was also conducted with electron microscopy. RESULTS: The total leukocyte increasing effective rate occurred in the treated group 1 was 75.00%, that in the treated group 2 was 88.89%, in the control group 1 was 54.55% and in the control group 2 was 58.33%. There was significant difference between the treated groups and the control groups (P < 0.01). Experimental study showed that SHSBG has good bone marrow hematopoietic microenvironmental protecting and improving effect in mice. CONCLUSION: SHSBG has obvious protecting and treating effect on CT caused bone marrow suppression in tumor patients.