Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001 Apr; 21(4): 257-9.

[Clinical observation on effect of intervention therapy with anticoagulant in treating patients of hypertension complicated with acute ischemic cerebrovascular disease]

Ma QC, Ma JS, Sun NL.

Department of Hypertension, People's Hospital of Beijing University, Beijing 100044.

OBJECTIVE: To study the changes of blood coagulation-fibrinolysis-C protein system in patients of hypertension with acute ischemic cerebrovascular disease (AICVD) after anticoagulation therapy. METHODS: Fifty-seven cases of AICVD were grouped and treated with heparin and Xueshuantong (XST) respectively, and the levels of prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), tissue plasminogen activator (t-PA), plasminogen activator inhibitor (PAI) and activated protein C (APC) were determined before and after treatment. RESULTS: The clinical markedly effective rate in the heparin group and the XST group was 69.2% and 67.7% respectively with no significant difference (P > 0.05). In the heparin group, level of PT and APTT prolonged, FIB decreased, t-PA activity elevated and PAI activity lowered, and APC unchanged. In the XST group, same changes in FIB, t-PA and PAI were shown but with APC increased, and PT and APTT unchanged. CONCLUSION: Both heparin and XST have good anticoagulatory function and show good clinical effect in treating patients with hypertension complicated with acute ischemic cerebrovascular diseases.